Multiple Aortic Thrombi Associated With Protein C and S Deficiency
نویسندگان
چکیده
منابع مشابه
Cerebral infarction associated with protein C deficiency.
BACKGROUND AND PURPOSE A deficiency of plasma protein C, both the hereditary and acquired types, is one cause of thromboembolic disease. Several antineoplastic agents have been reported to decrease the production of protein C in the liver by impairing either the absorption or metabolism of vitamin K, leading to acquired protein C deficiency. CASE DESCRIPTION We treated a young woman with prot...
متن کاملCardiac thrombi in a patient with protein-C and S deficiencies: a case report
We report a case of multiple mobile intra-cardiac thrombi accompanying recurrent pulmonary embolism that has been successfully treated by fibrinolytic therapy. Control transesophageal echocardiographic examination showed that prolonged thrombolytic treatment completely removed the thrombi. Surgical removal of emboli has been validated but cannot be proposed to all patients since it is a high-ri...
متن کاملProtein C and protein S deficiency - practical diagnostic issues.
Protein C (PC) and protein S (PS) are vitamin K-dependent glycoproteins, that act as natural anticoagulants. The proteolytic activation of PC by thrombin occurs on the surface of endothelial cells and involves thrombomodulin and endothelial PC receptor. In the presence of PS, phospholipids and calcium, activated PC (APC) inactivates membrane bound factors V (FVa) and FVIIIa by their cleavage at...
متن کاملRight atrial thrombosis associated with sagittal sinus thrombosis caused by protein C-S deficiency.
Right atrial thrombi may develop within the right atrium or may have peripheral venous origins that, on their way to the final destination site lodge in, right atrium. Right atrial thrombosis is classified as two type: A (mobile, thin) and B (non mobile and attached to atrial wall) that they are probably of cardiac origin due to local pathology, indwelling catheter, atrial fibrillation, stasis,...
متن کاملFamilial protein S deficiency is associated with recurrent thrombosis.
Recent studies have demonstrated that protein C deficiency is associated with recurrent familial thrombosis. In plasma, activated protein C functions as an anticoagulant. This anticoagulant response requires a vitamin K-dependent plasma protein cofactor, referred to as protein S. Since the anticoagulant activity of activated protein C is dependent on protein S, we hypothesized that patients lac...
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ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 2001
ISSN: 0025-6196
DOI: 10.4065/76.3.319